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If these drugs are to be used in the initial treatment of severe malaria, Lariam administration should be delayed at least 12 hours after the last dose. However, clinical experience with Lariam has not revealed an embryotoxic or teratogenic effect. Lariam should not be prescribed for prophylaxis in patients with active depression, a recent history of depression, generalized anxiety disorder, psychosis, or schizophrenia or other major psychiatric disorders, or with a history of convulsions. It is not known whether Lariam was responsible for those suicides. Nevertheless, the effects of Lariam on travelers receiving co-medication, particularly diabetics or patients using anticoagulants, should be checked before departure. In healthy volunteers, plasma concentrations peak 6 to 24 hours (median, about 17 hours) after a single dose of Lariam.
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